Science. 1965 Jun 11;148(3676):1471
Hereditary Absence of Sebaceous Glands in the Mouse.
Gates AH, Karasek M.
An autosomal recessive mutation, characterized by an absence of sebaceous glands, and by hyperkeratosis, alopecia (hair loss), and single (rather than the usual multiple) hair-follicle units, has occurred spontaneously in the BALB/c strain of mouse. Studies in which reciprocal transplantations of skin were made between normal and mutant mice suggest that some diffusible substance(s) synthesized by normal skin can stimulate hair regrowth and alleviate the hyperkeratosis characteristic of the skin syndrome.
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